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Altered SemmesWeinstein monofilament test results are associated with oxidative stress markers in type 2 diabetic subjects
Altered SemmesWeinstein monofilament test results are associated with oxidative stress markers in type 2 diabetic subjects
Different lines of evidence suggest that oxidative stress (OS) is implicated in the pathogenesis of diabetic neuropathy. The SemmesWeinstein monofilament (SWM) test is an efficient tool for evaluating diabetic polyneuropathy and diabetic foot. In this study, we analyzed the association between OS markers and altered SWM test results in type 2 diabetes (T2DM) patients.


Abstract
   
   Background
   Different lines of evidence suggest that oxidative stress (OS) is implicated in the pathogenesis of diabetic neuropathy. The SemmesWeinstein monofilament (SWM) test is an efficient tool for evaluating diabetic polyneuropathy and diabetic foot. In this study, we analyzed the association between OS markers and altered SWM test results in type 2 diabetes (T2DM) patients.
   
   Methods
   Seventy T2DM patients were studied and 34 showed altered SWM results. The clinical and biochemical parameters were determined using standardized methods. Levels of oxidized glutathione (GSSG) and malondialdehyde (MDA) were measured in circulating mononuclear cells using high-performance liquid chromatography.
   
   Results
   We found that T2DM patients with altered SWM test results had significantly higher GSSG (3.53 0.31 vs. 3.31 0.35 mmol/ml, p < 0.05) and MDA (1.88 0.16 vs. 1.75 0.19 nmol/ml, p < 0.01) values compared to diabetic patients with normal SWM test outcomes. Moreover, altered SWM test results were independently related to age, glycosylated hemoglobin, and GSSG levels, but there was no association between OS markers and altered neuropathy sensitivity score (NSS) values.
   
   Conclusions
   Alteration of the glutathione system and MDA values in T2DM patients are associated with loss of proprioceptive (pressure) sensitivity, but not with symptomatic polyneuropathy (as evaluated by NSS). This finding may be important for understanding how OS affects distal symmetric polyneuropathy in diabetic patients.
   
   Keywords
   
   Glutathione system Malondialdehyde Oxidative stress SemmesWeinstein monofilament test Peripheral polyneuropathy Type 2 diabetes mellitus
   
   more...

: medicine | ³: 0 | : 194 | 20/09/2017 Medicine and health - Common questions

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